Mostrando las entradas con la etiqueta Biotech. Mostrar todas las entradas
Mostrando las entradas con la etiqueta Biotech. Mostrar todas las entradas

lunes, 5 de octubre de 2020

Seattle biotech startup led by Fred Hutch, Adaptive vets raises $16M for rapid drug development tech

Lumen Chief Science Officer Jim Roberts (left) and CEO Brian Finrow. (Lumen Photo)

Lumen Bioscience today announced a $16 million Series B round to help support its novel approach to rapid and low-cost drug development.

The company has come up with a way to produce orally-delivered antibodies and other biologics by using a bioengineered bright green algae called Spirulina. It has three clinical programs to treat gastrointestinal diseases including C. difficile, norovirus, and traveler’s diarrhea.

Lumen CEO Brian Finrow said the company’s technology lowers the cost of biologic drugs by a factor of 1,000 or more.

“With traditional technologies there’s nowhere near enough manufacturing capacity in the world to treat and prevent these diseases in this way, but Lumen’s technology makes it feasible,” he said.

Lumen is led by Finrow, a former senior vice president at Adaptive Biotechnologies, and Chief Science Officer Jim Roberts, the former head of basic sciences at the Fred Hutchinson Cancer Research Institute. They co-founded the startup in 2017.

The 50-person company has several collaborations with organizations such as the Gates Foundation, NIH, NIAID, Fred Hutch, and others. It is currently working with the Gates Foundation to develop infectious disease drugs alongside fellow Seattle startup A-Alpha Bio.

WestRiver Management and Bioeconomy Capital led the round. Avista Development, Columbia Pacific, and local angels also participated, along with the co-founders. Total funding to date is $68 million.

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sábado, 12 de septiembre de 2020

Shares of Seattle biotech firm Omeros spike after reporting COVID-19 treatment results

Omeros stock shot up more than 60% after the Seattle-based biotech company reported promising results from its COVID-19 drug treatment.

The company said six COVID-19 patients in Italy with acute respiratory distress syndrome, or ARDS, recovered and were discharged from the hospital after being treated with Omeros’ drug narsoplimab. The patients initially required mechanical ventilation. Omeros is now in talks with U.S. government agencies to expand the availability of narsoplimab.

“The patients that we treated with narsoplimab were critically ill, and the uniformly successful outcomes were truly impressive,” Professor Rambaldi, a doctor at the Papa Giovanni XXIII Hospital, said in a statement. “Also of importance in this terribly sick population studied, the drug was well tolerated, showing no adverse effects.”

Founded in 1994, Omeros is one of Seattle’s largest biotech companies and went public in 2009. Revenue was down and losses grew in the second quarter due to postponements of cataract procedures. The company’s stock was down slightly Tuesday morning, trading at around $19/share.

“The work at Papa Giovanni, for the first time, puts many of the COVID-19 pieces together – endothelial injury and the pathophysiology of COVID-19, complement activation and clinical evidence of the potential therapeutic role of the lectin pathway inhibitor narsoplimab in treating this disease,” Gregory Demopulos, chairman and CEO of Omeros, said in a statement. “We look forward to being able to make narsoplimab broadly available to hospitalized COVID-19 patients.”

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viernes, 21 de agosto de 2020

New biotech startup GentiBio lands $20M, inks licensing deals with Seattle Children’s and BRI

Boston-based biotech startup GentiBio this week announced a $20 million funding round and licensing deals with two Seattle research institutions.

The company aims to treat autoimmune, alloimmune, autoinflammatory, and allergic diseases by developing engineered regulatory T cells, or Tregs. It is licensing technology from Seattle Children’s Research Institute, Benaroya Research Institute at Virginia Mason (BRI), and Israel-based MIGAL Galilee Research Institute (MIGAL).

Researchers from both Seattle Children’s and BRI helped launch GentiBio. The company is led by longtime biotech and life sciences industry exec Adel Nada.

“The technologies licensed from these premier research institutions are mature and well-differentiated, and will be further optimized in sponsored research collaborations with the scientific teams that discovered them to advance novel and potent therapeutics with the potential to treat and cure serious autoimmune and inflammatory diseases,” Nada said in a statement.

Investors in the seed round include OrbiMed, Novartis Venture Fund, and RA Capital Management.

GeekWire’s coverage this week is underwritten by BCRA

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miércoles, 29 de julio de 2020

Adaptive Biotech pushes ahead with new Seattle HQ, showing strength of life sciences industry

Chad Robins, CEO of Adaptive Biotechnologies, speaks at the site of the company’s future corporate headquarters in Seattle, standing in front of the final piece of structural steel before it’s put into place. (Stephen Brashear/AP Images for Adaptive Biotechnologies)

Topping-off ceremonies, in which workers place the last piece of structural steel for new building, have become run-of-the-mill over the past decade in Seattle’s South Lake Union neighborhood. But the recent event held by Adaptive Biotechnologies carried extra symbolic significance, due to the events swirling around it.

The pandemic has emptied large swaths of the surrounding neighborhood, including Amazon’s Seattle headquarters. (Construction workers and officials wore masks during the ceremony.) Meanwhile, new questions are emerging about the long-term role of Seattle and other traditional tech hubs in the innovation economy.

But biotech in Seattle “is just thriving right now,” said Chad Robins, the Adaptive Biotechnologies CEO, as he made his way to the ceremony at the new building, being developed by Alexandria Real Estate Equities at 1165 Eastlake Avenue E.

Part of the reason, he said, is the intersection of biotech and technology in the city.

Adaptive, which spun out of the Fred Hutchinson Cancer Research Center, works closely with Microsoft as part of its long-term quest to diagnose multiple diseases from a single blood test. Microsoft and Adaptive have been working in recent months to develop a new diagnostic test for COVID-19 as an extension of their partnership.

The future home of Adaptive Biotechnologies at 1165 Eastlake Avenue E. in Seattle. (Alexandria Real Estate Equities Rendering.)

“The convergence of biotechnology and technology in this city is a phenomenal aspect of what’s available to us,” Robins said.

In a recent report on life sciences hubs, real estate firm Cushman & Wakefield cited Adaptive’s partnership with Microsoft as an example of “a growing alliance between life sciences and tech companies” that “has set Seattle apart as an emerging hub.”

Adaptive is also partnering with Amgen to develop a new drug to treat and prevent COVID-19, using Adaptive’s system for sequencing the human immune system.

In recent years, demand has been high for a limited amount of lab and suitable office space for biotech companies in the city. Vacancy rates for lab space in Seattle fell below 3% earlier this year, according to the Cushman & Wakefield report, vs. more than 7.1% in 12 key markets covered in the report.

Adaptive announced its 100,000-square-foot lease of the facility in the fall of 2019, and plans to move in after the building is completed in about a year. The new facility gave Adaptive an opportunity to rethink its lab space to accommodate the needs of its current scientific workflows and processes, Robins said.

Adaptive Biotechnologies Chief Scientific Officer Harlan Robins signs the final beam during a “topping off” ceremony at the company’s future headquarters on Thursday, 23, 2020 in Seattle. (Stephen Brashear/AP Images for Adaptive Biotechnologies)

The building will also serve as Adaptive’s new headquarters, tripling its footprint in the city. It’s about a six-minute walk from Adaptive’s current space at 1551 Eastlake Ave. in Seattle, where the company plans to retain its presence.

Robins said the new building “is just the next, natural phase of growth for us and our immune-driven medicine platform.”

Adaptive has grown by more than 200 people over the past year, with more than 500 employees overall. Its employees who are able to do their jobs from home are working remotely, and the company says it has been maintaining strict safety protocols for researchers and others who need to work in its labs.

The company is not the only key member of the life sciences sector expanding in the city. Despite recent cutbacks, Fred Hutch is proceeding with plans to move into about 275 scientists and staff into 106,000-square feet in the renovated Seattle Steam Plant, the former home of biotech company Zymogenetics. The new space will expand Fred Hutch’s wet lab capacity by 15%. Move-in is set for late September and October, according to Fred Hutch officials.

Founded in 2009, Adaptive went public on the Nasdaq stock market in June 2019. It recently raised $240 million in a follow-on stock offering.

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