Seattle biotech startup led by Fred Hutch, Adaptive vets raises $16M for rapid drug development tech

Lumen Chief Science Officer Jim Roberts (left) and CEO Brian Finrow. (Lumen Photo)

Lumen Bioscience today announced a $16 million Series B round to help support its novel approach to rapid and low-cost drug development.

The company has come up with a way to produce orally-delivered antibodies and other biologics by using a bioengineered bright green algae called Spirulina. It has three clinical programs to treat gastrointestinal diseases including C. difficile, norovirus, and traveler’s diarrhea.

Lumen CEO Brian Finrow said the company’s technology lowers the cost of biologic drugs by a factor of 1,000 or more.

“With traditional technologies there’s nowhere near enough manufacturing capacity in the world to treat and prevent these diseases in this way, but Lumen’s technology makes it feasible,” he said.

Lumen is led by Finrow, a former senior vice president at Adaptive Biotechnologies, and Chief Science Officer Jim Roberts, the former head of basic sciences at the Fred Hutchinson Cancer Research Institute. They co-founded the startup in 2017.

The 50-person company has several collaborations with organizations such as the Gates Foundation, NIH, NIAID, Fred Hutch, and others. It is currently working with the Gates Foundation to develop infectious disease drugs alongside fellow Seattle startup A-Alpha Bio.

WestRiver Management and Bioeconomy Capital led the round. Avista Development, Columbia Pacific, and local angels also participated, along with the co-founders. Total funding to date is $68 million.

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Super spreaders drive COVID-19: 80% of those infected likely don’t spread disease, Fred Hutch study finds

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About 80% of people infected with the novel coronavirus don’t spread the infection to anyone else, leaving the so-called super spreaders as the drivers of the global pandemic that has infected more than 5 million Americans alone, killing 162,000 people.

Preliminary research from the Fred Hutchinson Cancer Research Center suggests that infected people are most contagious for a short window, perhaps only two days, when their virus load is high. Unfortunately, that period also appears to strike before they’re symptomatic for COVID-19.

“The ethical thing to do as an individual is to walk around with the assumption that you’re infectious and contagious, and that it’s your responsibility to protect the public. That doesn’t change at all,” said Dr. Joshua T. Schiffer, an infectious diseases physician and author of the research, in a statement.

 The ethical thing to do as an individual is to walk around with the assumption that you’re infectious and contagious.

The findings emphasize the importance of readily available, rapid tests to identify infections.

Infected people are likely spreading very small amounts of the virus over a longer period, possibly for weeks, but at levels that don’t sicken others. But when a person in a highly contagious state is in contact with a larger group of people, particularly in an indoor space or a situation where people aren’t using masks, the disease can take off.

The scientists ran roughly half a million simulations of the spread of the disease and matched them against data on actual COVID-19 infections. They reported that both influenza and COVID-19 have short windows during which they’re infectious, but the novel coronavirus’ ability to spread as an aerosol that is exhaled, coughed or sneezed appears to amplify its infectiousness. The researchers concluded that “approximately 10-20% of infected people account for 80% of SARS-CoV-2 transmissions.”

The research was posted Friday on MedRxiv, a platform for sharing studies before it goes through a rigorous peer review, giving scientists quicker access to the findings and a chance to discuss the results.

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